asdadas

Izindaba

Izitshalo zokwelapha zendabuko ziye zaziswa eminyakeni edlule ngokunikeza ukuqonda ngezinhlobonhlobo zezifo.Nokho, ukuhlukanisa ama-molecule athile asebenzayo endaweni yezinhlanganisela ezakha izinhlobo eziningi zezitshalo kungaba umsebenzi onzima.Manje, abacwaningi eNyuvesi yaseToyama, eJapane baye benza indlela yokuhlukanisa nokuhlonza izinhlanganisela ezisebenzayo emithini yezitshalo.

Drynaria1

Idatha entsha—eshicilelwe kamuva nje ku-Frontiers in Pharmacology esihlokweni esithi, “Isu Elihlelekile Lokuthola Umuthi Wokwelapha we-Alzheimer's Disease kanye ne-Target Molecule“, bonisa ukuthi indlela entsha ikhomba izinhlanganisela eziningana ezisebenzayo ezivela ku-Drynaria rhizome, umuthi wezitshalo wendabuko, othuthukisa inkumbulo futhi wehlise izici zesifo kumodeli yegundane lesifo i-Alzheimer's.

Ngokuvamile, ososayensi bazohlola ngokuphindaphindiwe imithi yezitshalo ezingahluziwe ekuhlolweni kwelebhu ukuze babone ukuthi ingabe ikhona yini inhlanganisela ebonisa umthelela kumaseli atshalwe ku-vitro.Uma inhlanganisela ibonisa umphumela omuhle kumaseli noma amashubhu okuhlola, ingase isetshenziswe njengesidakamizwa, futhi ososayensi bayaqhubeka nokuyihlola ezilwaneni.Nokho, le nqubo iwumsebenzi onzima futhi ayibaleli izinguquko ezingaba khona ezidakamizweni lapho zingena emzimbeni—ama-enzyme asegazini nesibindi angagaya izidakamizwa zibe izinhlobo ezihlukahlukene ezibizwa ngokuthi ama-metabolite.Ukwengeza, ezinye izindawo zomzimba, njengobuchopho, kunzima ukufinyelela kuzo izidakamizwa eziningi, futhi izidakamizwa ezithile kuphela noma ama-metabolites azo azongena kulezi zicubu.

"Izithako ezikhonjwe ezikrinini zemithi yezitshalo ezisezingeni eliphezulu azihlali zisebenza ngempela ngoba lezi zivivinyo azinaki i-biometabolism kanye nokusatshalaliswa kwezicubu," kuchaza umphenyi wocwaningo ophezulu u-Chihiro Tohda, Ph.D., uprofesa ohlanganyele we-neuropharmacology eNyuvesi yaseToyama. ."Ngakho-ke, sihlose ukuthuthukisa izindlela ezisebenza kahle kakhulu zokuhlonza izinhlanganisela ezisebenzayo ezicabangela lezi zici."

Drynaria2

Ocwaningweni, ithimba le-Toyama lasebenzisa amagundane anokuguqulwa kofuzo njengemodeli yesifo i-Alzheimer's.Lokhu kuguquka kunikeza amagundane izici ezithile zesifo i-Alzheimer's, okuhlanganisa inkumbulo encishisiwe kanye nokunqwabelana kwamaprotheni athile ebuchosheni, abizwa ngama-amyloid kanye nama-tau amaprotheni.

"Sibika isu elihlelekile lokuhlola abantu abasebenzisa i-bioactive emithini yemvelo esetshenziselwa isifo i-Alzheimer's (AD)," kubhala ababhali.“Sithole ukuthi i-Drynaria rhizome ingathuthukisa ukusebenza kwenkumbulo futhi ithuthukise i-AD pathologies kumagundane ayi-5XFAD.Ukuhlaziywa kwamakhemikhali ezinto eziphilayo kwaholela ekuhlonzweni kwama-metabolite asebenzayo adluliselwa ebuchosheni, okuyi-naringenin nama-glucuronides ayo.Ukuze sihlole indlela yokwenza, sihlanganise ukuzinza kwethagethi esabelayo ehambisana nezidakamizwa nokuhlaziywa kwe-immunoprecipitation-liquid chromatography/mass spectrometry, sihlonza iphrotheni yokusabela kwe-collapsin ye-protein 2 (CRMP2) njengento ehlosiwe ye-naringenin.”

Ososayensi bathola ukuthi ukukhishwa kwesitshalo kunciphisa ukukhubazeka kwenkumbulo kanye namazinga we-amyloid ne-tau amaprotheni ebuchosheni begundane.Ngaphezu kwalokho, ithimba libe selihlola izicubu zobuchopho begundane ngemva kwamahora amahlanu lilapha amagundane nge-extract.Bathola ukuthi izinhlanganisela ezintathu zesitshalo zazingene ebuchosheni—i-naringenin nama-naringenin metabolites amabili.

Lapho abaphenyi bephatha amagundane nge-naringenin emsulwa, baqaphela ukuthuthuka okufanayo kokusilela kwenkumbulo kanye nokuncipha kwamaprotheni e-amyloid kanye ne-tau, okusho ukuthi i-naringenin nama-metabolite ayo cishe kwakuyizinhlanganisela ezisebenzayo ngaphakathi kwesitshalo.Bathole iphrotheni ebizwa ngokuthi i-CRMP2 i-naringenin ebophezela kuyo kuma-neurons, okubangela ukuthi akhule, okuphakamisa ukuthi lena kungaba indlela i-naringenin engathuthukisa ngayo izimpawu zesifo i-Alzheimer's.

Abacwaningi banethemba lokuthi indlela entsha ingasetshenziswa ukukhomba ezinye izindlela zokwelapha.“Sisebenzisa le ndlela ukuze sithole imithi emisha yezinye izifo ezinjengokulimala komgogodla, ukucindezeleka, ne-sarcopenia,” kuphawula uDkt. Tohda.


Isikhathi sokuthumela: Mar-23-2022

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